The Inscopix DECODE Summit videos are open!

By Jami Milton, PhD | Nov 21, 2016 11:26:50 AM


The DECODE Summit videos feature thought leaders discussing scientific, technological and ecosystem challenges facing the scientific community, industry, nonprofits, and government. In a prior blog post , we promised to make the videos open, and I’m happy to say they are now available! To watch all 12 videos, go here .

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Inscopix Makes 2016 Deloitte Technology Fast 500™ List

By Kunal Ghosh, PhD | Nov 16, 2016 11:15:24 AM


We are so proud to announce that Inscopix has been named to the 2016 Deloitte Technology Fast 500™ List! The brain needs champions, and our inclusion in this year’s list is a big win for neuroscience and the human brain.

Released today, the Deloitte Fast Technology 500™ recognizes the most innovative and fastest-growing North American technology companies transforming the future of business. From life sciences to software and semiconductors, the Fast 500 spans all areas of technology and is widely held as one of the industry’s most prestigious and longest-running technology innovator rankings.

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Integrated optogenetics and calcium imaging in one tiny microscope, nVoke

By Jami Milton, PhD | Nov 15, 2016 1:56:40 PM

It’s been an exciting Neuroscience 2016. The community has presented over 30 talks and posters featuring Inscopix technology, and there are now over 20 publications. We’re so proud of the advances we’ve made together. We’re constantly collaborating with researchers to put forward cutting-edge technology so that we can bring tour-de-force circuit-level investigations of brain function and behavior within reach of all neuroscientists. Our collaborations toward the common goal of catalyzing scientific breakthroughs allow us to innovate for the benefit of the neuroscience ecosystem. It’s exactly because of this collaborative effort we’re able to announce the release of a new product, nVoke, into early access. Read today’s press release here.  Watch a video about nVoke here.

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The DECODE Summit: A multi-stakeholder gathering on the translational value of neural circuit research

By Kunal Ghosh, PhD | Nov 1, 2016 10:32:13 AM


“Progress in science depends on new techniques, new discoveries, and new ideas, probably in that order.” – Sydney Brenner

It was an honor and privilege to have hosted the DECODE Summit at the Four Seasons in Palo Alto on September 28th, 2016, bringing together stakeholders across distinct nodes of the neuroscience community. In the coming weeks we’ll make the talks and Keynote Panels open and available on our website and through other channels. In the meantime, I’d like to offer some brief remarks on why we hosted the Summit, including the genesis of DECODE -- an innovative grant program we launched in 2014 with a $2M investment to “crowdsource” the discovery of neural circuit signatures of disease.

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On the Road to The White House Frontiers Conference

By Kunal Ghosh, PhD | Oct 12, 2016 5:44:09 PM

Three years ago, President Obama announced the White House BRAIN Initiative. It was a moment I’ll never forget. In an instant, the President of the United States made our very existence a national priority.

Tomorrow, I have the honor and pleasure of attending the White House Frontiers Conference at Carnegie Mellon, a special, invitation-only ‘meeting of the minds’ highlighting innovation in America and the Administration's achievements in brain research, artificial intelligence, personal medicine and cleantech.

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Neural Circuits of Social Memory

By Jami Milton, PhD | Oct 11, 2016 4:20:38 PM

You know that situation when you run into someone from your past, but it takes a while to register how you know them? I had this experience a couple of weeks ago at the DECODE Summit, an ambitious event hosted by Inscopix that brought together stakeholders across the neuroscience community, from academia, government, non-profits, industry, and pharma to grapple with big questions on translating the circuit basis of disease (search #DECODESummit for live tweets from the event). With so many minds meeting from different sectors, a lot of us were seeing folks we hadn’t seen in quite some time, which meant in addition to thinking about the big questions in neuroscience, our brains were constantly discerning familiar faces during the event. According to exciting new research on social memory in mice, we can thank a very specific circuit in our hippocampus for holding the memory –or engram– of whether someone is familiar or a stranger.

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Two-Photon Versus One-Photon In Vivo Imaging for Understanding the Neural Circuit Basis of Behavior

By Jami Milton, PhD | Sep 26, 2016 8:14:11 PM

Our exciting DECODE Summit kicks off this week (I’ll tell you much more about DECODE in future posts, but for now read here how the goal is to incentivize investigators to pursue groundbreaking brain research), and you’d think I wouldn’t have the time to squeeze in a blog post, but I can’t help myself, because we have a very cool white paper that I want you to know about right away. Neuroscientists, check this out! If you’re interested in expanding your optical brain imaging toolbox for understanding the neural circuit basis of behavior, then you’ll want to read this white paper comparing one-photon to two-photon in vivo calcium imaging.

To download the white paper “Two-Photon and Miniaturized One-Photon Microscopy A Technology Discussion for Neural Circuit Imaging”, go here.

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[News Roundup] The Beginning of A New Chapter in Brain Mapping

By Jami Milton, PhD | Sep 6, 2016 10:45:58 AM

The last few weeks have been really great for Inscopix, and we’re feeling incredibly grateful! The recent close of a $10M Series A round led by Playground Global marks the close of a successful first chapter in the Inscopix story and the beginning of a second chapter. We’re thrilled about this new chapter, and proud of what our team of scientists and engineers have accomplished toward enabling researchers across the globe, in academia and industry, to push scientific boundaries for brain mapping.

For more about Inscopix and our recent financing news, check out the articles linked below.

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Miniaturized microscope tech gives scientists the ability to study the neural circuits of sleep

By Jami Milton, PhD | Aug 25, 2016 9:44:24 AM

Technology can enable our lives in positive ways, if used wisely. Take my experience just over the last twelve hours. Last night I downloaded a sleep app that wakes you up at an optimal point in your sleep cycle. In other words, it makes sure the alarm doesn’t go off during REM (rapid eye movement) sleep, when you’re dreaming, or deep sleep. How a mobile phone app accurately measures sleep cycles is still a mystery to me (an accelerometer?), but I can say that this morning, I was ready to get up with the alarm (a novel experience for me) and felt remarkably well rested, even with only seven hours of sleep. Tech for the win!

How well we sleep has a huge impact on our daily lives, making it a fascinating area of research. A recent study in mice takes a fresh look at the neural circuits involved in sleep by applying enabling tech. The scientists employed a miniaturized microscope targeted to the dorsal pons, an area at the base of the brain that is thought to first generate REM sleep. This tech gave researchers the ability to reach a deep brain area and record activity from individually identified neurons while mice freely transitioned between sleep and wake cycles. Plus, they recorded activity from a large-scale ensemble of neurons simultaneously, greatly facilitating data collection.

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Large Scale Neural Circuit Dynamics Underlying Learning and Memory

By Jami Milton, PhD | Aug 19, 2016 11:06:11 AM

Of all the amazing feats our brains perform, our ability to form, store, and retrieve memories stands out as one of the most fascinating, and challenging areas of neuroscience study. Despite the complexity, scientists have made significant inroads into understanding how many of the molecular and synaptic pieces of the puzzle fit together. However, we still have much to learn about the network properties of long-term memory. How can we gain insight into this neuronal communication network?

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