Miniaturized microscope tech gives scientists the ability to study the neural circuits of sleep

By Jami Milton, PhD | Aug 25, 2016 9:44:24 AM

Technology can enable our lives in positive ways, if used wisely. Take my experience just over the last twelve hours. Last night I downloaded a sleep app that wakes you up at an optimal point in your sleep cycle. In other words, it makes sure the alarm doesn’t go off during REM (rapid eye movement) sleep, when you’re dreaming, or deep sleep. How a mobile phone app accurately measures sleep cycles is still a mystery to me (an accelerometer?), but I can say that this morning, I was ready to get up with the alarm (a novel experience for me) and felt remarkably well rested, even with only seven hours of sleep. Tech for the win!

How well we sleep has a huge impact on our daily lives, making it a fascinating area of research. A recent study in mice takes a fresh look at the neural circuits involved in sleep by applying enabling tech. The scientists employed a miniaturized microscope targeted to the dorsal pons, an area at the base of the brain that is thought to first generate REM sleep. This tech gave researchers the ability to reach a deep brain area and record activity from individually identified neurons while mice freely transitioned between sleep and wake cycles. Plus, they recorded activity from a large-scale ensemble of neurons simultaneously, greatly facilitating data collection.

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Large Scale Neural Circuit Dynamics Underlying Learning and Memory

By Jami Milton, PhD | Aug 19, 2016 11:06:11 AM

Of all the amazing feats our brains perform, our ability to form, store, and retrieve memories stands out as one of the most fascinating, and challenging areas of neuroscience study. Despite the complexity, scientists have made significant inroads into understanding how many of the molecular and synaptic pieces of the puzzle fit together. However, we still have much to learn about the network properties of long-term memory. How can we gain insight into this neuronal communication network?

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Inscopix expands scientific advisory board with appointment of leading neuroscientists

By Dr. Pushkar Joshi | Aug 9, 2016 11:26:32 AM

Palo Alto, CA, August 9, 2016/-- Inscopix, Inc., announced the addition of four distinguished brain research experts, Botond Roska (FMI), Hongkui Zeng (AIBS), Scott Sternson (Janelia), and Surya Ganguli (Stanford), to its Scientific Advisory Board (SAB). The new members will join Eric Nestler (Mt. Sinai)  and Guoping Feng (MIT). The SAB will work closely with Inscopix’s executive, and science and engineering teams to provide strategic guidance for research and development activities in support of the company’s ambitious technology road-map for revolutionizing real-time brain activity mapping.

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Neuroscience study shows how context matters for sticks, but not carrots

By Jami Milton, PhD | Aug 3, 2016 9:31:48 AM

This is the first post in a series where we get to showcase breakthrough work from our customers and collaborators.

In our environments, we’re constantly presented with things we find rewarding (like the Bulbasaur Pokémon I caught today), or downright annoying. Regardless of what we like and can do without, we encode these preferences, and hopefully remember them, so we can fulfill our goal to get what we want, and avoid what we don’t. Mice, too, quickly learn goal-directed behavior.

In a recent paper, Thomas Harrison, and colleagues in Yang Dan’s lab, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, tease apart neural mechanisms which code different aspects of goal-directed behavior. They focus on a brain structure called the basal forebrain, buried deep in the front of our brains.

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Inscopix ACCELERATE Summer Workshop

By Jacqueline DeRose, PhD | Jul 29, 2016 10:56:37 AM
Inscopix kicked off their 7th two-day educational workshop event on July 25-26, 2016. The workshop is designed to give scientists in-depth training on Inscopix’s imaging (nVista) and analysis (Mosaic) systems as well as in-house laboratory demonstrations using Inscopix’s imaging devices. Scientists and customers from six institutions across four countries attended the event and took the opportunity to communicate freely with one another and with Inscopix’s scientists and engineers on their ideas and experiences using this cutting-edge technology.
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A Deeper Look Into the Brain

By Jami Milton, PhD | Jul 26, 2016 12:14:37 PM

 

This week scientists from industry and academia are convening at our Palo Alto headquarters from around the world to learn more about the Inscopix nVista platform. The nVista platform is built around our proprietary miniature microscope that can be mounted on the head of an animal subject to monitor the activities of brain cells in real time. At our ACCELERATE workshop, we’re training the scientists on all the ins and outs of nVista, from end to end, including hands-on lab time.

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Miniature fluorescence microscopy platform for imaging neural circuits launches commercially

By Lee Dubay | Apr 8, 2016 10:24:39 AM

 

Inscopix (Palo Alto, CA) has brought its nVista brain imaging platform—which can view upwards of 1000 neurons simultaneously in one field of view—to market. Originally only accessible through the Neuroscience Early Access Program (NEAP), Inscopix plans to expand the system's reach to the widest spectrum of neuroscience investigators through packages customized for specific researcher needs.

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Inscopix is proud to be the Corporate Sponsor of the April 7th Art Live Lounge fundraiser for the Global Fund for Women

By Inscopix | Apr 5, 2016 3:22:42 PM

 

Women in science and industry face unique challenges, from finding rewarding careers in a tough economic climate, to achieving tenure and leadership roles in high pressure work environments amid unbalanced social expectations. 

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Inscopix Exits Early Access Phase to Publicly Launch End-to-End Platform for Imaging Neural Circuit Activity

By Inscopix | Apr 5, 2016 6:00:00 AM

 

PALO ALTO, Calif., April 4, 2016 /PRNewswire/ -- Inscopix Inc., today announced the commercial launch of its nVista brain imaging platform to the neuroscience research community. Centered on a patented miniature microscope technology from Stanford University, the nVista system is a significant technological advance that decodes the neural language underlying brain function and behavior. Originally only accessible through the Neuroscience Early Access Program (NEAP), Inscopix plans to expand the reach of nVista to the widest spectrum of neuroscience investigators through packages customized for specific researcher needs.

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Inscopix prepares for new era in neuroscience

By Tim Hayes | Mar 30, 2016 2:54:00 PM

Mapping neuron activity in live animals is a key step for researchers,
but now industry needs to play its part.

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