On the Road to The White House Frontiers Conference

By Kunal Ghosh, PhD | Oct 12, 2016 5:44:09 PM

Three years ago, President Obama announced the White House BRAIN Initiative. It was a moment I’ll never forget. In an instant, the President of the United States made our very existence a national priority.

Tomorrow, I have the honor and pleasure of attending the White House Frontiers Conference at Carnegie Mellon, a special, invitation-only ‘meeting of the minds’ highlighting innovation in America and the Administration's achievements in brain research, artificial intelligence, personal medicine and cleantech.

Read More >

Neural Circuits of Social Memory

By Jami Milton, PhD | Oct 11, 2016 4:20:38 PM

You know that situation when you run into someone from your past, but it takes a while to register how you know them? I had this experience a couple of weeks ago at the DECODE Summit, an ambitious event hosted by Inscopix that brought together stakeholders across the neuroscience community, from academia, government, non-profits, industry, and pharma to grapple with big questions on translating the circuit basis of disease (search #DECODESummit for live tweets from the event). With so many minds meeting from different sectors, a lot of us were seeing folks we hadn’t seen in quite some time, which meant in addition to thinking about the big questions in neuroscience, our brains were constantly discerning familiar faces during the event. According to exciting new research on social memory in mice, we can thank a very specific circuit in our hippocampus for holding the memory –or engram– of whether someone is familiar or a stranger.

Read More >

Two-Photon Versus One-Photon In Vivo Imaging for Understanding the Neural Circuit Basis of Behavior

By Jami Milton, PhD | Sep 26, 2016 8:14:11 PM

Our exciting DECODE Summit kicks off this week (I’ll tell you much more about DECODE in future posts, but for now read here how the goal is to incentivize investigators to pursue groundbreaking brain research), and you’d think I wouldn’t have the time to squeeze in a blog post, but I can’t help myself, because we have a very cool white paper that I want you to know about right away. Neuroscientists, check this out! If you’re interested in expanding your optical brain imaging toolbox for understanding the neural circuit basis of behavior, then you’ll want to read this white paper comparing one-photon to two-photon in vivo calcium imaging.

To download the white paper “Two-Photon and Miniaturized One-Photon Microscopy A Technology Discussion for Neural Circuit Imaging”, go here.

Read More >

[News Roundup] The Beginning of A New Chapter in Brain Mapping

By Jami Milton, PhD | Sep 6, 2016 10:45:58 AM

The last few weeks have been really great for Inscopix, and we’re feeling incredibly grateful! The recent close of a $10M Series A round led by Playground Global marks the close of a successful first chapter in the Inscopix story and the beginning of a second chapter. We’re thrilled about this new chapter, and proud of what our team of scientists and engineers have accomplished toward enabling researchers across the globe, in academia and industry, to push scientific boundaries for brain mapping.

For more about Inscopix and our recent financing news, check out the articles linked below.

Read More >

Miniaturized microscope tech gives scientists the ability to study the neural circuits of sleep

By Jami Milton, PhD | Aug 25, 2016 9:44:24 AM

Technology can enable our lives in positive ways, if used wisely. Take my experience just over the last twelve hours. Last night I downloaded a sleep app that wakes you up at an optimal point in your sleep cycle. In other words, it makes sure the alarm doesn’t go off during REM (rapid eye movement) sleep, when you’re dreaming, or deep sleep. How a mobile phone app accurately measures sleep cycles is still a mystery to me (an accelerometer?), but I can say that this morning, I was ready to get up with the alarm (a novel experience for me) and felt remarkably well rested, even with only seven hours of sleep. Tech for the win!

How well we sleep has a huge impact on our daily lives, making it a fascinating area of research. A recent study in mice takes a fresh look at the neural circuits involved in sleep by applying enabling tech. The scientists employed a miniaturized microscope targeted to the dorsal pons, an area at the base of the brain that is thought to first generate REM sleep. This tech gave researchers the ability to reach a deep brain area and record activity from individually identified neurons while mice freely transitioned between sleep and wake cycles. Plus, they recorded activity from a large-scale ensemble of neurons simultaneously, greatly facilitating data collection.

Read More >

Large Scale Neural Circuit Dynamics Underlying Learning and Memory

By Jami Milton, PhD | Aug 19, 2016 11:06:11 AM

Of all the amazing feats our brains perform, our ability to form, store, and retrieve memories stands out as one of the most fascinating, and challenging areas of neuroscience study. Despite the complexity, scientists have made significant inroads into understanding how many of the molecular and synaptic pieces of the puzzle fit together. However, we still have much to learn about the network properties of long-term memory. How can we gain insight into this neuronal communication network?

Read More >

Inscopix expands scientific advisory board with appointment of leading neuroscientists

By Dr. Pushkar Joshi | Aug 9, 2016 11:26:32 AM

Palo Alto, CA, August 9, 2016/-- Inscopix, Inc., announced the addition of four distinguished brain research experts, Botond Roska (FMI), Hongkui Zeng (AIBS), Scott Sternson (Janelia), and Surya Ganguli (Stanford), to its Scientific Advisory Board (SAB). The new members will join Eric Nestler (Mt. Sinai)  and Guoping Feng (MIT). The SAB will work closely with Inscopix’s executive, and science and engineering teams to provide strategic guidance for research and development activities in support of the company’s ambitious technology road-map for revolutionizing real-time brain activity mapping.

Read More >

Neuroscience study shows how context matters for sticks, but not carrots

By Jami Milton, PhD | Aug 3, 2016 9:31:48 AM

This is the first post in a series where we get to showcase breakthrough work from our customers and collaborators.

In our environments, we’re constantly presented with things we find rewarding (like the Bulbasaur Pokémon I caught today), or downright annoying. Regardless of what we like and can do without, we encode these preferences, and hopefully remember them, so we can fulfill our goal to get what we want, and avoid what we don’t. Mice, too, quickly learn goal-directed behavior.

In a recent paper, Thomas Harrison, and colleagues in Yang Dan’s lab, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, tease apart neural mechanisms which code different aspects of goal-directed behavior. They focus on a brain structure called the basal forebrain, buried deep in the front of our brains.

Read More >

Inscopix ACCELERATE Summer Workshop

By Jacqueline DeRose, PhD | Jul 29, 2016 10:56:37 AM
Inscopix kicked off their 7th two-day educational workshop event on July 25-26, 2016. The workshop is designed to give scientists in-depth training on Inscopix’s imaging (nVista) and analysis (Mosaic) systems as well as in-house laboratory demonstrations using Inscopix’s imaging devices. Scientists and customers from six institutions across four countries attended the event and took the opportunity to communicate freely with one another and with Inscopix’s scientists and engineers on their ideas and experiences using this cutting-edge technology.
Read More >

A Deeper Look Into the Brain

By Jami Milton, PhD | Jul 26, 2016 12:14:37 PM


This week scientists from industry and academia are convening at our Palo Alto headquarters from around the world to learn more about the Inscopix nVista platform. The nVista platform is built around our proprietary miniature microscope that can be mounted on the head of an animal subject to monitor the activities of brain cells in real time. At our ACCELERATE workshop, we’re training the scientists on all the ins and outs of nVista, from end to end, including hands-on lab time.

Read More >
Explore nVista