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Hunger logic

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Activation of AgRP-expressing 'hunger' neurons promotes robust feeding. Recent studies reveal the valence, dynamics and neural circuits engaged by AgRP neurons.

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Figure 1: Logic of AgRP neuron signaling.

References

  1. Krashes, M.J. et al. J. Clin. Invest. 121, 1424–1428 (2011).

    Article  CAS  Google Scholar 

  2. Aponte, Y., Atasoy, D. & Sternson, S.M. Nat. Neurosci. 14, 351–355 (2011).

    Article  CAS  Google Scholar 

  3. Luquet, S., Perez, F.A., Hnasko, T.S. & Palmiter, R.D. Science 310, 683–685 (2005).

    Article  CAS  Google Scholar 

  4. Garfield, A.S. et al. Nat. Neurosci. 18, 863–871 (2015).

    Article  CAS  Google Scholar 

  5. Betley, J.N. et al. Nature published online, doi:10.1038/nature14416 (27 April 2015).

  6. Broberger, C., Johansson, J., Johansson, C., Schalling, M. & Hokfelt, T. Proc. Natl. Acad. Sci. USA 95, 15043–15048 (1998).

    Article  CAS  Google Scholar 

  7. Betley, J.N., Cao, Z.F.H., Ritola, K.D. & Sternson, S.M. Cell 155, 1337–1350 (2013).

    Article  CAS  Google Scholar 

  8. Cone, R.D. Nat. Neurosci. 8, 571–578 (2005).

    Article  CAS  Google Scholar 

  9. Carter, M.E., Soden, M.E., Zweifel, L.S. & Palmiter, R.D. Nature 503, 111–114 (2013).

    Article  CAS  Google Scholar 

  10. Jennings, J.H. et al. Cell 160, 516–527 (2015).

    Article  CAS  Google Scholar 

  11. Chen, Y., Lin, Y.C., Kuo, T.W. & Knight, Z.A. Cell 160, 829–841 (2015).

    Article  Google Scholar 

  12. Wu, Q., Boyle, M.P. & Palmiter, R.D. Cell 137, 1225–1234 (2009).

    Article  Google Scholar 

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Correspondence to Richard Palmiter.

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The author declares no competing financial interests.

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Palmiter, R. Hunger logic. Nat Neurosci 18, 789–791 (2015). https://doi.org/10.1038/nn.4032

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